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Naproxen, naproxen sodium are members of the
non-steroidal anti-inflammatory drug (NSAIDs) family. NSAIDs reduce
inflammation (swelling), pain, and temperature. Naproxen is used to treat
mild to moderate pain, osteoarthritis, rheumatoid arthritis, ankylosing
spondylitis, primary dysmenorrhea, tendinitis, bursitis, and other
conditions. Naproxen and naproxen sodium are available in prescription
strength; naproxen sodium is also available in nonprescription strength.
Naproxen, Naproxen sodium, Naprosyn, Naprelan,
Anaprox, Aleve |
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Naproxen Sodium
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30 Naproxen 500mg |
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Male
Female
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60 Naproxen 500mg |
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90 Naproxen 500mg |
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30 Naproxen Sodium 550mg |
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Male
Female
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60 Naproxen Sodium 550mg |
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90 Naproxen Sodium 550mg |
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Generic Naprosyn
(Naproxen) |
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The following information is
intended to supplement, not substitute for, the expertise and
judgment of your physician, pharmacist or other healthcare
professional. It should not be construed to indicate that use of
the drug is safe, appropriate, or effective for you. Consult
your healthcare professional before using this drug.
Online Naproxen Use Indication:
Mild to
moderate pain. Musculoskeletal and soft tissue inflammation
including rheumatoid arthritis, osteoarthritis, bursitis,
tendinitis, ankylosing spondylitis. Primary dysmenorrhea, acute
gout. Juvenile rheumatoid arthritis (naproxen only). NOTE: The
delayed-release or enteric-coated products are not recommended
for initial treatment of pain because, compared to other
naproxen products, absorption is delayed. Investigational:
Antipyretic in cancer clients, sunburn, acute migraine (sodium
salt only), prophylaxis of migraine, migraine due to menses, PMS
(sodium salt only). OTC. Relief of minor aches and pains due to
the common cold, headache, toothache, muscular aches, backache,
minor arthritis pain, pain due to menstrual cramps. Decrease
fever.
Medication Naproxen Side Effects:
Most
patients benefit from naproxen and other NSAIDs with few side
effects. However, serious side effects can occur, and generally
tend to be dose related. Therefore, it is often desirable to use
the lowest effective dose to minimize side effects. The most
common side effects of naproxen involve the gastrointestinal
system. It can cause ulcerations, abdominal burning, pain,
cramping, nausea, gastritis, and even serious gastrointestinal
bleeding and liver toxicity. Sometimes, stomach ulceration and
bleeding can occur without any abdominal pain. Black tarry
stools, weakness, and dizziness upon standing may be the only
signs of internal bleeding. Rash, kidney impairment, ringing in
the ears, and lightheadedness can also occur.
Precautions on using Naproxen
Simultaneous use of naproxen and naproxen sodium.
Special Concerns: Safety and effectiveness of naproxen have not
been determined in children less than 2 years of age; the safety
and effectiveness of naproxen sodium have not been established
in children. Geriatric clients may manifest increased total
plasma levels of naproxen.
All
naproxen products are contraindicated in patients who have had
allergic reactions to prescription as well as to over- the-
counter products containing naproxen. It is also contraindicated
in patients in whom aspirin or other nonsteroidal anti-
inflammatory/ analgesic drugs induce the syndrome of asthma,
rhinitis, and nasal polyps. Both types of reactions have the
potential of being fatal. Anaphylactoid reactions to naproxen,
whether of the true allergic type or the pharmacologic
idiosyncratic ( eg, aspirin hypersensitivity syndrome) type,
usually but not always occur in patients with a known history of
such reactions. Therefore, careful questioning of patients for
such things as asthma, nasal polyps, urticaria, and hypotension
associated with nonsteroidal anti- inflammatory drugs before
starting therapy is important. In addition, if such symptoms
occur during therapy, treatment should be discontinued.
Medication Naproxen / Naproxen Sodium Drug Interaction:
Methotrexate / Possibility of a fatal interaction Probenecid /
Plasma clearance of naproxen. Concomitant administration of
naproxen and aspirin is not recommended because naproxen is
displaced from its binding sites during the concomitant
administration of aspirin, resulting in lower plasma
concentrations and peak plasma levels.
The natriuretic effect of furosemide has been reported to be
inhibited by some drugs of this class. Inhibition of renal
lithium clearance leading to increases in plasma lithium
concentrations has also been reported. Naproxen and other
nonsteroidal anti- inflammatory drugs can reduce the
antihypertensive effect of propranolol and other betablockers.
Probenecid given concurrently increases naproxen anion plasma
levels and extends its plasma half- life significantly.
Caution should be used if naproxen is administered concomitantly
with methotrexate. Naproxen, naproxen sodium and other
nonsteroidal anti- inflammatory drugs have been reported to
reduce the tubular secretion of methotrexate in an animal model,
possibly increasing the toxicity of methotrexate.
Medication
Naproxen Overdose:
Significant Naproxen overdosage may be characterized by
drowsiness, heartburn, indigestion, nausea or vomiting. Because
Naproxen sodium may be rapidly absorbed, high and early blood
levels should be anticipated. A few patients have experienced
seizures, but it is not clear whether or not these were drug-
related. It is not known what dose of the drug would be life-
threatening. The oral LD 50 of the drug is 543 mg/ kg in rats,
1234 mg/ kg in mice, 4110 mg/ kg in hamsters, and greater than
1000 mg/ kg in dogs.
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